The City Press reports it has well-placed sources indicating she will soon be charged with conspiracy to commit murder.
Ntuli-Zuma was apparently banned from the Nkandla homestead earlier this year following claims of a plot to poison Zuma.
It's understood a docket has been opened with the National Prosecuting Authority (NPA) with sources saying Ntuli-Zuma has made a statement to investigators.
The City Press is reporting that while sources in the NPA say top bosses are aware of the matter, spokesperson Vuyo Mfaku has denied this.
An investigation is now underway to find out whether NPA staff leaked information about the probe.
Ntuli-Zuma was first suspected when the president became ill in June 2014.
Zuma was told that he had been poisoned by more than one doctor during his trip to the US in August last year.
