In a statement in Abuja, the APC said Mrs Jonathan's recent description of the presidential candidate of the party, General Muhammadu Buhari as "brain-dead" was both insulting and demeaning.
President Goodluck Jonathan has thus been urged to call his wife to order immediately.
The statement signed by the Director, Media and Publicity Unit of the organisation, Mallam Garba Shehu, observed that "it was discourteous and inexcusable for a wife of any president with a modicum of decency to make such a false and infantile pronouncement about the health status of another man on account of politics."
The APCPCO further recalled another of Mrs Jonathan's statement in Calabar, Cross River State where she urged PDP supporters to "stone" all those canvassing for change, saying she was invoking violence.
The statement added that it was below the standard of a wife of a president to stoop so low to call for violent attacks against members of the opposition.